[학술지 논문 게재] Hepatokines as a Molecular Transducer of Exercise N
No.1344480
Hepatokines as a Molecular Transducer of Exercise
Journal of Clinical Medicine, 2021, 10(3), 385.
by Dae Yun Seo 1, Se Hwan Park 2, Jubert Marquez 1,Hyo-Bum Kwak 3,Tae Nyun Kim 1, Jun Hyun Bae 4, Jin-Ho Koh 5 and Jin Han 1
1. National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Smart Marine Therapeutics Center, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
2. School of Kinesiology, Yeungnam University, Gyeongsan 38541, Korea
3. Department of Kinesiology, Inha University, Incheon 22212, Korea
4. Institute of Sport Science, Seoul National University, Seoul 08826, Korea
5. Department of Physiology, College of Medicine, Yeungnam University, Daegu 42415, Korea
Abstract
Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), and cardiovascular disease (CVD). Besides this, the importance of the liver as an endocrine organ is a hot research topic. Hepatocytes also secrete many hepatokines in response to nutritional conditions and/or physical activity. In particular, certain hepatokines play a major role in the regulation of whole-body metabolic homeostasis. In this review, we summarize the recent research findings on the exercise-mediated regulation of hepatokines, including fibroblast growth factor 21, fetuin-A, angiopoietin-like protein 4, and follistatin. These hepatokines serve as molecular transducers of the metabolic benefits of physical activity in chronic metabolic diseases, including NAFLD, T2D, and CVDs, in various tissues.